Loss is an inevitable part of life that can lead to significant grief and pain. The death of a loved one, a breakup, job loss or any unwanted change to one’s circumstances can feel devastating. Loss comes in many forms that can lead to grief, including: The death of a loved one - losing a family member, friend or pet can bring profound sorrow. Romantic breakups and divorces - the end of a committed relationship can deeply shake someone's world. Job loss - being laid off, down